Switching Lamivudine with Adefovir Dipivoxil Combination Therapy to Entecavir Monotherapy Provides Better Viral Suppression and Kidney Safety
نویسندگان
چکیده
منابع مشابه
Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy
The emergence of entecavir (ETV) resistance is rare, particularly in a longitudinal study. The aim of the present study was to characterize the evolution of ETV-resistant variants during antiviral therapy using entecavir monotherapy followed by ETV-adefovir dipivoxil (ADV) combination therapy. The study included a prospective cohort of 53 consecutive chronic hepatitis B (CHB) patients. During t...
متن کاملLong-term efficacy of entecavir plus adefovir combination therapy versus entecavir monotherapy in adefovir refractory chronic hepatitis B patients with prior lamivudine resistance.
OBJECTIVES We investigated the long-term efficacy of entecavir (ETV) + adefovir (ADV) combination therapy versus ETV monotherapy in lamivudine (LAM)-resistant chronic hepatitis B (CHB) patients who failed to respond to ADV rescue therapy. METHODS A total of 91 ADV refractory patients with prior LAM resistance received ETV (1.0 mg/day) + ADV (10 mg/day) combination therapy (group A, n = 45) or...
متن کاملEfficacy of Adefovir - based Combination Therapy for Patients with 1 Lamivudine - and Entecavir - Resistant Chronic Hepatitis
Authors: 6 Yun Bin Lee (e-mail: [email protected]) 1 7 Jeong-Hoon Lee (e-mail: [email protected]) 1 8 Won-mook Choi (e-mail: [email protected]) 1 9 Young Youn Cho (e-mail: [email protected]) 1 10 Jeong-ju Yoo (e-mail: [email protected]) 1 11 Minjong Lee (e-mail: [email protected]) 1 12 Dong Hyeon Lee (e-mail: [email protected]) 1 13 Yuri Cho (e-mail: [email protected]) 1 14 Su J...
متن کاملLong-term adefovir dipivoxil monotherapy for up to 5 years in lamivudine-resistant chronic hepatitis B.
BACKGROUND Large clinical studies assessing long-term adefovir dipivoxil salvage monotherapy in patients with lamivudine-resistant chronic hepatitis B (CHB) are lacking, particularly in patients positive for hepatitis B e antigen (HBeAg). We assessed the efficacy and resistance profile of adefovir dipivoxil monotherapy for up to 5 years in a large cohort of Korean patients with lamivudine-resis...
متن کاملEntecavir plus tenofovir versus entecavir plus adefovir in chronic hepatitis B patients with a suboptimal response to lamivudine and adefovir combination therapy
BACKGROUND/AIMS We compared the efficacies of entecavir (ETV) plus tenofovir (TDF) and ETV plus adefovir (ADV) in chronic hepatitis B (CHB) patients with genotypic resistance to lamivudine (LAM) who showed a suboptimal response to LAM and ADV combination therapy. METHODS We reviewed 63 CHB patients with genotypic resistance to LAM who showed a suboptimal response to LAM and ADV combination th...
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ژورنال
عنوان ژورنال: International Journal of Medical Sciences
سال: 2019
ISSN: 1449-1907
DOI: 10.7150/ijms.28700